Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores.
نویسندگان
چکیده
We report the detection of homocysteine over cysteine based upon characteristic differences between 5- and 6-membered heterocyclic amines formed upon reaction with aldehyde-bearing compounds. Homocysteine-derived thiazinane-4-carboxylic acids are more basic than cysteine-derived thiazolidines-4-carboxylic acids. Fluorescence enhancement in response to homocysteine is achieved by tuning pH and excitation wavelength.
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عنوان ژورنال:
- Chemical communications
دوره 50 60 شماره
صفحات -
تاریخ انتشار 2014